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A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients.

机译：一种新的功能性CYP3A4内含子6多态性显着影响他克莫司在肾移植受体中的药代动力学。

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摘要

Tacrolimus (Tac) is a potent immunosuppressant with considerable toxicity. Tac pharmacokinetics varies between individuals and thus complicates its use in preventing rejection after kidney transplantation. This variability might be caused by genetic polymorphisms in metabolizing enzymes.

机译：他克莫司（Tac）是一种有效的免疫抑制剂，具有相当大的毒性。 Tac的药代动力学因人而异，因此使其在预防肾移植后排斥反应方面的用途复杂化。这种变异性可能是由于代谢酶的遗传多态性引起的。

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作者
Elens, Laure; Bouamar, Rachida; Hesselink, Dennis A; Haufroid, Vincent; van der Heiden, Ilse P; van Gelder, Teun; van Schaik, Ron H N;
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年度 2011
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正文语种 eng
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1. A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients. [J] . Elens L, Bouamar R, Hesselink DA, Clinical Chemistry: Journal of the American Association for Clinical Chemists . 2011,第11期

机译：新的功能性CYP3A4内含子6多态性显着影响他克莫司在肾移植受体中的药代动力学。
2. Effect of CYP3A4*22 and CYP3A4*1B but not CYP3A5*3 polymorphisms on tacrolimus pharmacokinetic model in Tunisian kidney transplant [J] . Hannachi Ibtissem, Ben Fredj Nadia, Chadli Zohra, Toxicology and Applied Pharmacology . 2020,第1期

机译：CYP3A4 * 22和CYP3A4 * 1B但不是CYP3A5 * 3多态性在突尼斯肾移植中的CYP3A5 * 3多态性
3. Effects of CYP3A4 and CYP3A5 polymorphisms on tacrolimus pharmacokinetics in Chinese adult renal transplant recipients: A population pharmacokinetic analysis [J] . ZuoX.-C., NgC.M., BarrettJ.S., Pharmacogenetics and genomics . 2013,第5期

机译：CYP3A4和CYP3A5多态性对中国成人肾移植受者他克莫司药代动力学的影响：人群药代动力学分析
4. ASSOCIATION OF CYP3A4 * 18B POLYMORPHISMS WITH THE PHARMACOKINETICS OF TACROLIMUS IN CHINESE RENAL TRANSPLANT RECIPIENTS [C] . Li Danying, Fang Yun, Teng Ruichen Progress on post-genome technologies and modern natural products . 2011

机译：CYP3A4 * 18B多态性与中国肾移植患者滑石M药代动力学的关系
5. The pharmacokinetics and pharmacodynamics of mycophenolic acid in kidney transplant recipients. [D] . Patel, Chirag G. 2006

机译：麦考酚酸在肾移植受者中的药代动力学和药效学。
6. Effects of the CYP3A4*1B Genetic Polymorphism on the Pharmacokinetics of Tacrolimus in Adult Renal Transplant Recipients: A Meta-Analysis [O] . Wei-Long Shi, Hui-Lin Tang, Suo-Di Zhai -1

机译：CYP3A4 * 1B基因多态性对他克莫司在成人肾移植受者中药代动力学的影响：荟萃分析
7. A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients [O] . Elens, Laure, Bouamar, Rachida, Hesselink, Dennis, 2011

机译：一种新的功能性CYP3A4内含子6多态性显着影响他克莫司在肾移植受者中的药代动力学

A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients.

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